Here's another article I found on his main premise, which he's been pounding on since 1999: Do I think the cumulative lifetime effect of mitochondrial free radicals might have a place in a theory of aging? Sure. Is it even the major part? Probably not. It's interesting to note that SENS still has his 1999 book on the subject on its website. I would not bother to read a 16 year old book on biology. A paper, yes. If it was a seminal one. But a book? That was in production for over a year, maybe 2, and references older material because of that? No way. Most of my literature searches have a cutoff of 5 years. Sometimes 10, but rarely. Science moves faster than that, and the primary means to disseminate scientific thinking is the journal article, not books. Books take too long to produce. The review article is a much better way to communicate the current thinking in a broad subject. The fact that they still have that book out (especially when the link between telomeres and aging was only a few years old and not well-accepted when it went to press) makes my Laffy-guru radar beep like crazy.